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Benzquinamide hydrochloride

CAS No. 113-69-9

Benzquinamide hydrochloride( 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride )

Catalog No. M28949 CAS No. 113-69-9

Benzquinamide hydrochloride is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Benzquinamide hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Benzquinamide hydrochloride is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance.
  • Description
    Benzquinamide hydrochloride is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance.(In Vivo):Benzquinamide (0.5 to 5 mg/kg; i.v.) caused tachycardia, elevated blood norepinephrine levels, frequent ventricular arrhythmias, and brief hypotension. Ganglionic blockade by hexamethonium prior to administration of benzquinamide prevented the tachycardia and alterations in norepinephrine levels but prolonged the period of hypotension. In isolated mesenteric arterial preparations, benzquinamide interfered with the contractile force generated by potassium chloride, norepinephrine, and prostaglandin F2 alpha.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TLR7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    113-69-9
  • Formula Weight
    442.977
  • Molecular Formula
    C22H35ClN2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CCN(CC)C(=O)C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nakamura T, et al. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72.
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